Mix together brown sugar, whiskey, pineapple juice, soy sauce, garlic powder, onion powder, Worcestershire sauce, Dijon mustard, and hot pepper sauce in a medium bowl until well combined.
Heat grapeseed oil in a nonstick pan over medium-high heat.
Place salmon fillets skin-side up into the pan and cook for about 4 minutes, allowing them to develop a light brown crust.
Flip the salmon fillets over and generously brush with the whiskey glaze prepared earlier.
Preheat your oven to 350°F (175°C).
Transfer the pan with salmon fillets into the oven and bake for about 6 minutes, or until the salmon is cooked through.
Remove the salmon from the oven and allow it to rest for a couple of minutes before serving.
Enjoy your homemade whiskey glazed salmon!