Mix all the spices together in a small bowl.

Combine Cajun seasoning, paprika, garlic powder, onion powder, salt, and black pepper.

Rub the spice mix evenly over both sides of the salmon fillets.

Make sure the fillets are coated well.

Heat a large pan over medium-high heat and melt the butter until it’s sizzling hot.

Add the salmon fillets to the pan, skin-side down first.

Cook for 4-6 minutes on each side, depending on the thickness of the fillets.

Remove the fillets from the pan and place them on a plate.

Garnish with lemon slices before serving.