Preheat your oven to 350 degrees Fahrenheit.
You’ll want a baking dish ready for the catfish fillets.
In a bowl, mix together the Cajun seasoning, paprika, salt, black pepper, garlic powder, onion powder, and cayenne pepper.
This spice mixture will coat the catfish.
Generously rub both sides of each catfish fillet with the spice mixture.
Each piece should be evenly seasoned for the best flavor.
In a skillet, melt the butter over medium heat.
Carefully add the fillets, cooking for about 2 minutes on each side or until slightly blackened.
Transfer the skillet to the preheated oven and bake for about 10 minutes until the fish is cooked through and flakes easily with a fork.